Peptide Publications Archive
GLP-1s Block Amyloid
Limbocker Lab
Millions of people already take GLP-1 receptor agonists for diabetes and weight loss, but whether these drugs directly interfere with the molecular machinery of Alzheimer's …
Profiling Transpeptidase Targets
Pires Lab
Tuberculosis kills more than a million people each year, yet the enzymes that stitch together its cell wall remain poorly understood and difficult to target. …
Steering Cysteine Chemistry
Tsai Lab
Most reagents that target N-terminal cysteine consume both the amine and thiol, locking the ligation site into an inert heterocycle. A new steric-control strategy forces …
Paired Library Pursuit
Suga Lab
Most peptide discovery platforms find one binder at a time. A new library-vs-library extension of the RaPID system pairs two 10¹²-member macrocyclic peptide libraries and …
Hydrazino Turn Hunters
Suga Lab
α-Hydrazino acids have long tantalized peptide chemists with their turn-inducing and protease-resisting properties, yet no one had managed to screen them de novo against protein …
Backbone Heteroatom Shield
Del Valle Lab
Replacing backbone amide nitrogens with nitrogen or oxygen heteroatoms can slow protease degradation without sacrificing the folded structures peptides need to work. A tetra-N-aminated antimicrobial …
Breaching Candida
van der Donk Lab
A class II lanthipeptide from the cyanobacterium Nostoc punctiforme kills Candida species by disrupting cell membranes, marking the first antifungal activity reported for this lanthipeptide …
Tuning Incretin Balance
Kumar Lab
A single chemical edit at the N-terminus of a GLP-1/GIP/glucagon multiagonist can shift receptor potency balance by orders of magnitude, selectively suppress β-arrestin recruitment, or …
Stapling LRRK2
Kennedy Lab
Hydrocarbon-stapled peptides that mimic the C-terminal helix of LRRK2 can penetrate cells, bind the kinase directly, and suppress its hyperactivation without triggering the mislocalization side …
Yeast Finds Inhibitors
Angelini Lab
Yeast display technology, long used to evolve antibodies, can now rapidly surface macrocyclic peptide inhibitors of human angiotensin-converting enzyme 2 with potencies in the low-nanomolar …
Chameleonic Proline Rings
Palma Lab
A new family of all-peptide macrocycles built from alternating L- and D-proline tetramers flips between two distinct conformations depending on solvent, solves long-standing functionalization challenges …
Ansamers Target Integrins
Yao Lab
Bicyclic peptides derived from the amanitin scaffold can exist as non-interconvertible conformational isomers called ansamers, and the two mirror-like forms can differ by orders of …
Lipid-Hijacking RiPPs
van der Donk Lab
Bacteria already possess a well-oiled machinery for anchoring lipoproteins to their membranes. A new study reveals that a family of ribosomally synthesized peptides has co-opted …
DarF Decoded
Phan Lab
An enzyme in the darobactin biosynthetic pathway had been classified as a protease for years. New biochemical evidence shows it is actually an α-ketoglutarate-dependent oxidase …
Porous Collagen Crystals
Merg Lab
Collagen-mimetic peptides are renowned for triple-helix rigidity, but no one had channeled that rigidity into a porous crystalline framework. Now, by appending a single alkyl …
Scalable Azapeptide Macrocycles
Lubell Lab
A convergent solution-phase strategy for a potent macrocyclic azapeptide CD36 modulator sidesteps preparative chromatography entirely, delivering 100 mg of >99%-pure material by swapping an oligomer-prone …
Hairpins Hold the Key
Hall, Radford, and Brockwell Labs
A single methionine swap in α-synuclein's N-terminal P1 motif dismantles the β-hairpin architecture that normally launches amyloid fibril formation
Activating Native Termini
Raj Lab
Thiazoline and thiazole macrocycles embedded in bioactive marine peptides have long required pre-built specialty building blocks that slow synthesis and risk epimerization. A new palladium-mediated …
Bump-Gap Filaments
Chenoweth Lab
Natural collagen carries risks of immunogenicity and resists chemical modification, but synthetic collagen-mimetic peptides have struggled to match its continuous, mechanically robust fibrillar architecture. A …
Labeling Serine Selectively
Chen Lab
Serine and threonine hydroxyl groups are among the most difficult side chains to modify selectively in complex peptides, yet they govern phosphorylation, glycosylation, and enzyme …
Chaperone Orientation Rules
Gierasch Lab
Three closely related Hsp70 molecular chaperones grip the same model peptides in strikingly different orientations: bacterial DnaK shows no directional preference, human Hsc70 leans toward …
Silencing Strep Signals
Tal-Gan Lab
Streptococcus sinensis is an oral commensal that turns deadly when it reaches the bloodstream, causing infective endocarditis with roughly 25% mortality. A new mutational map …
Fragment Capping PDZ
Wilson Lab
β-strand-mediated protein–protein interactions are among the hardest targets in chemical biology, and PDZ domains are notoriously resistant to small-molecule ligands. A dynamic ligation screen against …
Stabilizing SNEW
Sawyer Lab
The EphB2 receptor drives several cancers, yet its best peptide inhibitor, SNEW, has languished with modest potency and poor serum stability. Swapping its N-terminal serine …